N-羟基胞苷
N(4)-hydroxycytidine
| 货号 | 包装规格 | 纯度/级别 | 交货周期 | 价格 | 数量 |
|---|---|---|---|---|---|
| YB563399-5mg | 5mg | 98% | 现货 | ||
| YB563399-10mg | 10mg | 98% | 现货 | ||
| YB563399-50mg | 50mg | 98% | 现货 | ||
| YB563399-250mg | 250mg | 98% | 现货 | ||
| YB563399-1g | 1g | 98% | 现货 | ||
| YB563399-5g | 5g | 98% | 现货 |
| 中文名称 | N-羟基胞苷 |
|---|---|
| 英文名称 | N(4)-hydroxycytidine |
| 别名 | N-羟基胞苷 | N-羟基胞苷(NHC(EIDD-1931)) |
| Cas No. | 3258-02-4 |
| 精确分子量 | 259.08044 |
| Smiles | C1C(NO)=NC(=O)N([C@@H]2O[C@H](CO)[C@@H](O)[C@H]2O)C=1 |
| 密度 | 1.93±0.1 g/cm3(Predicted) |
|---|---|
| 信号词 | Warning |
| 熔点 | 169-172 °C |
| 化学稳定性 | DMSO或蒸馏水中的溶液可在-20°下稳定储存3个月。 |
| 运输要求 | 低温冰袋运输 |
| 特性 | * |
| 用途 | Beta-d-N4-hydroxycytidine 是一种非常有效的抗委内瑞拉马脑炎病毒剂 (anti-VEEV) ，EC50， EC90 和 EC99 分别为 0.426，1.036 和 2.5 μM。 |
| 水溶解性 | 可溶于DMSO（高达25mg/ml）或水（加热时高达15mg/ml）。 |
| 符号 | GHS07 |
| 存储要求 | -20°C储存,密闭,干燥 |
EIDD-1931 (Beta-d-N4-hydroxycytidine, β-d-N4-hydroxycytidine, NHC)是EIDD-2801的活性代谢产物，它是一种很有前途的 COVID-19 抑制剂。 EIDD-1931（NHC）对 SARS-CoV-2、MERS-CoV、SARS-CoV 和 related zoonotic group 2b或2c Bat-CoVs，对应的平均IC50值为0.15 μM，并且对带有对核苷类似物抑制剂remdesivir耐药性突变的冠状病毒的效力增强。
体外研究
Beta-d-N4-hydroxycytidine is an anti-VEEV (venezuelan equine encephalitis virus) agent with EC 50 , EC 90 , and EC 99 are 0.426, 1.036, and 2.5 μM, respectively.Beta-d-N4-hydroxycytidine inhibits CHIKV replicon activity and the 50% effective concentration (EC 50 ) s 0.8 μM in the Huh-7–CHIKV replicon cell line. Similar results is presented with the replicon in BHK-21 cells (EC 50 =1.8 μM). NHC has no cytotoxicity for NHC in the Huh-7 cell culture system until up to 100 μM using MTT assays. The 50% cytotoxic concentration (CCsub>50) values for NHC are determined to be 30.6 μM, 7.7 μM, and 2.5 μM in peripheral blood mononuclear (PBM), Vero, and CEM cells, respectively.NHC behaves as a pyrimidine analog, NHC-mediated inhibition of the CHIKV replicon can be abrogated by the addition of exogenous nucleosides, such as pyrimidines C and U, but dA, dC, dG, dU, or T has no impact on the replicon. Pyrimidines A and G contributes to replicon inhibition both in the presence and in the absence of NHC.
