1-(2-噻唑基偶氮)-2-萘酚
1-(2-THIAZOLYLAZO)-2-NAPHTHOL
| 货号 | 包装规格 | 纯度/级别 | 交货周期 | 价格 | 数量 |
|---|---|---|---|---|---|
| YB560663-200mg | 200mg | >99.0%(T) | 现货 | ||
| YB560663-1g | 1g | >99.0%(T) | 现货 | ||
| YB560663-5g | 5g | >99.0%(T) | 现货 | ||
| YB560663-25g | 25g | >99.0%(T) | 现货 |
| 中文名称 | 1-(2-噻唑基偶氮)-2-萘酚 |
|---|---|
| 英文名称 | 1-(2-THIAZOLYLAZO)-2-NAPHTHOL |
| 别名 | 1-(2’-噻唑偶氮)-2-萘酚 | 1-(2-噻唑偶氮)-2-萘酚 | 1-(2-噻唑基偶氮)-2-萘酚 | 1-(2'-噻唑基偶氮)-2-萘酚 | 2-(2-羟基-1-萘基偶氮)噻唑 | 1-(2-联氮噻吩)-2-萘酚 |
| Cas No. | 1147-56-4 |
| MDL No. | MFCD00021611 |
| 精确分子量 | 255.04663 |
| Smiles | C1C=C2C=CC(O)=C(N=NC3SC=CN=3)C2=CC=1 |
| 密度 | 1.40 |
|---|---|
| 信号词 | 警告 |
| 危险类别(旧) | 36/37/38 |
| 熔点 | 138-139 °C |
| 化学稳定性 | 可在-20°C下的DMSO溶液保存长达1个月。 |
| 沸点 | 464.8±47.0 °C(Predicted) |
| 海关编码 | 2927.00.5000 |
| 特性 | * |
| 用途 | [过渡金属用分光光度试剂] |
| 安全说明(旧) | 22-24/25 |
| 水溶解性 | methanol: 10 mg/mL, clear |
| 符号 | GHS07 |
| 存储要求 | 室温储存 |
NSC139021 (ERGi-USU) 是ERG阳性癌细胞生长的高度选择性抑制剂，抑制不同细胞系的 IC50 值为 30 到400 nM。
靶点
IC50: 30 to 400 nM (ERG-positive cancer cells)
体外研究
NSC139021 selectively inhibits growth of ERGpositive cancer cell lines with minimal effect on normal prostate or endothelial cells or ERG-negative tumor cell lines. The IC 50 of NSC139021 for cell growth inhibition of responsive cell lines range between 30 nM to 400 nM. Combination of NSC139021 with enzalutamide shows additive effects in inhibiting growth of VCaP cells. A screen of kinases reveal that NSC139021 directly bound the ribosomal biogenesis regulator atypical kinase RIOK2 and induces ribosomal stress signature.
体内研究
NSC139021 treatment inhibits growth of ERG-positive VCaP tumor xenografts with no apparent toxicity. Significant (P<0.05, P<0.005) inhibition of tumor growth is noted at day 26 in treatment groups indicating 44% (100 mg/kg) and 65% (150 mg/kg) reduction of tumor burden. At 100 mg/kg and 150 mg/kg, no apparent toxicity including weight loss, lethargy, diarrhea, loss of appetite, respiratory distress, or overall drug related toxicity is observed. .
