红倍酚
PURPUROGALLIN
| 货号 | 包装规格 | 纯度/级别 | 交货周期 | 价格 | 数量 |
|---|---|---|---|---|---|
| YB00291-1mg | 1mg | 95% | 现货 | ||
| YB00291-5mg | 5mg | 95% | 现货 | ||
| YB00291-25mg | 25mg | 95% | 现货 | ||
| YB00291-100mg | 100mg | 95% | 现货 |
| 中文名称 | 红倍酚 |
|---|---|
| 英文名称 | PURPUROGALLIN |
| 别名 | 红陪酚 |
| Cas No. | 569-77-7 |
| MDL No. | MFCD00004145 |
| 精确分子量 | 220.03718 |
| Smiles | C1C=C(O)C(=O)C2C(=CC(O)=C(O)C=2O)C=1 |
| 密度 | 1.74g/cm3 |
|---|---|
| 信号词 | 警告 |
| 危险类别(旧) | 36/37/38 |
| 存储条件 | ?20°C |
| 熔点 | 274.5 °C (decomp) |
| 化学稳定性 | 空气敏感 |
| 沸点 | 275ºC (dec.)(lit.) |
| 运输要求 | 低温冰袋运输 |
| 海关编码 | 2914400090 |
| 特性 | * |
| 安全说明(旧) | S26;S36 |
| 水溶解性 | 可溶于DMSO（少许）、甲醇（少许） |
| 符号 | GHS07 |
| 存储要求 | 贮存： ：-20℃ |
| 闪点 | 184.5ºC |
Purpurogallin 是从栎属植物中提取的天然酚，具有强的黄嘌呤氧化酶 (Xanthine Oxidase) 抑制活性，其 IC50 为 0.2 µM。Purpurogallin 具有抗氧化和抗炎作用。
靶点
IC50: 0.2 µM (xanthine oxidase)
体外研究
Purpurogallin (50 or 100 µM; 7 or 25 hours; BV2 murine microglial cells) treatment attenuates the production of pro-inflammatory cytokines, including interleukin-1β (IL-1β) and tumor necrosis factor-α (TNF-α) by suppressing their mRNA and protein expression in LPS-stimulated BV2 microglial cells.
Purpurogallin (100 µM; 75-120 minutes; BV2 murine microglial cells) exhibits anti-inflammatory properties by suppressing the phosphatidylinositol 3-kinase/Akt and mitogen-activated protein kinase signaling pathways in LPS-stimulated BV2 microglial cells.
RT-PCR
| Cell Line: | BV2 murine microglial cells |
| Concentration: | 50 or 100 µM |
| Incubation Time: | 7 or 25 hours |
| Result: | Attenuated the production of pro-inflammatory cytokines, including interleukin-1β (IL-1β) and tumor necrosis factor-α (TNF-α) by suppressing their mRNA and protein expression. |
Western Blot Analysis
| Cell Line: | BV2 murine microglial cells |
| Concentration: | 100 µM |
| Incubation Time: | 75 minutes, 90 minutes, 120 minutes |
| Result: | Suppressed the phosphatidylinositol 3-kinase/Akt and mitogen-activated protein kinase signaling pathways. |
体内研究
Purpurogallin (100-400 μg/kg; intraperitoneal injection; for 48 or 72 hours; male Sprague-Dawley rats) exerts its neuroinflammation effect through the dual effect of inhibiting IL-6 and TNF-α mRNA expression and reducing HMGB1 protein and mRNA expression.
| Animal Model: | Fifty-four male Sprague-Dawley rats (250-350 g) with subarachnoid hemorrhage (SAH) |
| Dosage: | 100 μg/kg, 200 μg/kg, 400 μg/kg |
| Administration: | Intraperitoneal injection; for 48 or 72 hours |
| Result: | Dose-dependently reduced HMGB1 protein expression. High dose reduced TNF-α and HMGB1 mRNA levels. |
